Product Overview
(S, R, S)-AHPC-Me dihydrochloride | T13671L | TargetMol Chemicals
CAS: T13671L
Smiles: N[C@@H](C(C)(C)C)C(N1[C@H](C(N[C@@H](C)C2=CC=C(C3=C(C)N=CS3)C=C2)=O)C[C@@H](O)C1)=O.Cl.Cl
Formula: C23H34Cl2N4O3S
Pathway: Others
Target: Others
Receptor: N/A
Bioactivity: (S, R, S)-AHPC-Me dihydrochloride can be used to synthesize ARV-771, a von Hippel-Landau (VHL) E3 ligase-based BET PROTAC degrader. ARV-771 potently degrades BET protein in castration-resistant prostate cancer (CRPC) cells with a DC50 <1 nM. (S, R, S)-AHPC-Me dihydrochloride (VHL ligand 2 dihydrochloride) is the (S, R, S)-AHPC-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein.
Molecular Weight: 517, 51
