Product Overview
(S, R, S)-AHPC-Me hydrochloride | T13671 | TargetMol Chemicals
CAS: 1948273-03-7
Smiles: Cl.C[C@H](NC(=O)[C@@H]1C[C@@H](O)CN1C(=O)[C@@H](N)C(C)(C)C)c1ccc(cc1)-c1scnc1C
Formula: C23H33ClN4O3S
Pathway: Others
Target: Others
Receptor: N/A
Bioactivity: (S, R, S)-AHPC-Me hydrochloride can be used to synthesize ARV-771, a von Hippel-Landau (VHL) E3 ligase-based BET PROTAC degrader. ARV-771 potently degrades BET protein in castration-resistant prostate cancer (CRPC) cells with a DC50 <1 nM. (S, R, S)-AHPC-Me hydrochloride (VHL ligand 2 hydrochloride) is the (S, R, S)-AHPC-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein.
Molecular Weight: 481, 05
