Product Overview
(S, R, S)-AHPC-Me | T7752 | TargetMol Chemicals
CAS: 1948273-02-6
Smiles: C[C@H](NC(=O)[C@@H]1C[C@@H](O)CN1C(=O)[C@@H](N)C(C)(C)C)c1ccc(cc1)-c1scnc1C
Formula: C23H32N4O3S
Pathway: N/A
Target: N/A
Receptor: N/A
Bioactivity: (S, R, S)-AHPC-Me (VHL ligand 2) is the (S, R, S)-AHPC-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein[1]. (S, R, S)-AHPC-Me can be used to synthesize ARV-771. ARV-771 is a von Hippel-Landau (VHL) E3 ligase-based BET PROTAC degrader. ARV-771 potently degrades BET protein in castration-resistant prostate cancer (CRPC) cells with a DC50 <1 nM.
Molecular Weight: 444, 59
