Product Overview
(S, R, S)-AHPC TFA | T17927 | TargetMol Chemicals
CAS: 1631137-51-3
Smiles: FC(F)(F)C(O)=O.O=C([C@H](C[C@@H](O)C1)N1C([C@@H](N)C(C)(C)C)=O)NCC2=CC=C(C(SC=N3)=C3C)C=C2
Formula: C24H31F3N4O5S
Pathway: Others
Target: Others
Receptor: N/A
Bioactivity: (S, R, S)-AHPC TFA (VH032-NH2 TFA) is the VH032-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S, R, S)-AHPC TFA can be connected to the ligand for protein (e.g., BCR-ABL1) by a linker to form PROTACs (e.g., GMB-475). GMB-475 induces the degradation of BCR-ABL1 with an IC50 of 1.11 μM in Ba/F3 cells.
Molecular Weight: 544, 59
