Product Overview
S39625 | T28648 | TargetMol Chemicals
CAS: 536711-20-3
Smiles: CC[C@@]1(O)C(=O)Cc2c1cc1-c3nc4cc5OCOc5cc4c(C4CCC4)c3Cn1c2=O
Formula: C25H22N2O5
Pathway: N/A
Target: N/A
Receptor: N/A
Bioactivity: S39625, an E-ring camptothecin keto analogue, is a stable, potent, and selective topoisomerase I inhibitor without being substrates of drug efflux transporters. Nanomolar concentrations of S39625 induces intense and persistent histone gamma-H2AX. The chemical stability of the keto analogues and the ability of S39625 to produce high levels of persistent Top1-DNA cleavage complex and its potent antiproliferative activity against human cancer cell lines make S39625 a promising new anticancer drug candidate.
Molecular Weight: 430, 46