Product Overview
S49076 HCl | T3512 | TargetMol Chemicals
CAS: 1265966-31-1
Smiles: Cl.O=C1CSC(=O)N1Cc1ccc2NC(=O)\C(=C/c3cc(CN4CCOCC4)c[nH]3)c2c1
Formula: C22H23ClN4O4S
Pathway: Angiogenesis|||Tyrosine Kinase/Adaptors
Target: FGFR|||c-Met/HGFR|||TAM Receptor
Receptor: N/A
Bioactivity: S49076 is an effective inhibitor of MET, AXL/MER, and FGFR1/2/3. S49076 potently blocked cellular phosphorylation of MET, AXL, and FGFRs and inhibited downstream signaling in vitro and in vivo. In cell models, S49076 inhibited the proliferation of MET- and FGFR2-dependent gastric cancer cells blocked MET-driven migration of lung carcinoma cells, and inhibited colony formation of hepatocarcinoma cells expressing FGFR1/2 and AXL. In tumor xenograft models, a good pharmacokinetic/pharmacodynamic relationship for MET and FGFR2 inhibition following oral administration of S49076 was established and correlated well with impact on tumor growth.
Molecular Weight: 474, 96
