Product Overview
Sanggenon C | T4S1615 | TargetMol Chemicals
CAS: 80651-76-9
Smiles: CC(C)=CCC12Oc3cc(O)c([C@H]4C=C(C)C[C@@H]([C@H]4C(=O)c4ccc(O)cc4O)c4ccc(O)cc4O)c(O)c3C(=O)C1(O)Oc1cc(O)ccc21
Formula: C40H36O12
Pathway: NF-Κb
Target: NF-κB
Receptor: N/A
Bioactivity: 1. Sanggenone C inhibits tumor cellular proteasomal activity and cell viability, via induction of cell cycle arrest and cell death, inhibiting the proteasome function. 2. Sanggenone C and O inhibited NO production and iNOS expression by suppressing NF-κB activity and IκBα activation; inhibited TNF-alpha -stimulated PMN-HSC adhesion and expression of VCAM-1 by suppressing the activation of NF-kappaB.
Molecular Weight: 708, 716
