Product Overview
SB-218078 | T16848 | TargetMol Chemicals
CAS: 135897-06-2
Smiles: O=C1NC(=O)c2c1c1c3ccccc3n3C4CCC(O4)n4c5ccccc5c2c4c13
Formula: C24H15N3O3
Pathway: Cell Cycle/Checkpoint|||Chromatin/Epigenetic|||Cytoskeletal Signaling
Target: Chk|||PKC
Receptor: N/A
Bioactivity: SB-218078 is less potently inhibits Cdc2 (IC50: 250 nM) and PKC (IC50: 1000 nM). SB-218078 is a potent, ATP-competitive, and cell-permeable checkpoint kinase 1 inhibitor that inhibits Chk1 phosphorylation of cdc25C (IC50: 15 nM).
Molecular Weight: 393, 402
