Product Overview
Schisandrol B | T6S1917 | TargetMol Chemicals
CAS: 58546-54-6
Smiles: COc1cc2C[C@](C)(O)[C@@H](C)Cc3cc4OCOc4c(OC)c3-c2c(OC)c1OC
Formula: C23H28O7
Pathway: Autophagy|||Immunology/Inflammation|||Metabolism|||NF-Κb
Target: P450|||Reactive Oxygen Species|||Autophagy
Receptor: N/A
Bioactivity: 1. Gomisin A may exert neuroprotective effects by attenuating the microglia-mediated neuroinflammatory response via inhibiting the TLR4-mediated NF-κB and MAPKs signaling pathways. 2. Gomisin A has anti-inflammatory property, potentially result from the inhibition of COX-2, iNOS, IL-6, TNF-α and NO through the down-regulation of RIP2 and NF-κB activation. 3. Gomisin A induces marked protective effects against hepatic and renal injury induced by CCl(4) exposure through differential regulation of the MAPK signal transduction pathway. 4. Gomisin A significantly inhibits cell proliferation in a dose-dependent manner, due to cell cycle arrest in the G1 phase with the downregulation of cyclin D1 expression and Retinoblastoma (RB) phosphorylation.
Molecular Weight: 416, 47
