Product Overview
Setipiprant | T3520 | TargetMol Chemicals
CAS: 866460-33-5
Smiles: OC(=O)Cn1c2CCN(Cc2c2cc(F)ccc12)C(=O)c1cccc2ccccc12
Formula: C24H19FN2O3
Pathway: Endocrinology/Hormones|||GPCR/G Protein|||Immunology/Inflammation
Target: GPR|||Prostaglandin Receptor
Receptor: N/A
Bioactivity: Setipiprant is an orally available, selective CRTH2 antagonist (IC50: 6.0 nM). CRTH2 is a G protein-coupled receptor for prostaglandin (PGD2). PGD2 is produced by the mast cells and is a key mediator in various inflammatory diseases, including allergy and asthma. Binding of PGD2 to CRTH2, which are expressed on the surface of blood-borne cells, induces chemotaxis of Th2 cells, basophils, and eosinophils, and stimulates cytokine release from these cells.
Molecular Weight: 402, 425
