Product Overview
SHP099 | T3564 | TargetMol Chemicals
CAS: 1801747-42-1
Smiles: CC1(N)CCN(CC1)c1cnc(c(N)n1)-c1cccc(Cl)c1Cl
Formula: C16H19Cl2N5
Pathway: Apoptosis|||Metabolism
Target: Phosphatase|||PERK
Receptor: N/A
Bioactivity: SHP099 free base is an effective, selective, orally bioavailable, and efficacious SHP2 inhibitor (IC50 =0.07 μM and p-ERK modulation in cells IC50 = 0.250 μM). SHP099 shows dose-dependent pathway inhibition and antitumor activity in xenograft models.
Molecular Weight: 352, 26
