Product Overview
SirReal1-O-propargyl | T18641 | TargetMol Chemicals
CAS: 1862237-99-7
Smiles: Cc1cc(C)nc(SCC(=O)Nc2ncc(Cc3cccc(OCC#C)c3)s2)n1
Formula: C21H20N4O2S2
Pathway: Others
Target: Others
Receptor: N/A
Bioactivity: SirReal1-O-propargyl is a selective and highly potent Sirtuin 2 (Sirt2) inhibitor, with an IC50 of 2.4 μM. SirReal1-O-propargyl, the SirReal1-based moiety, binds to the cereblon ligand via a linker to form PROTAC to degrade Sirt2[1].
Molecular Weight: 424, 54
