Product Overview
SKF-96365 hydrochloride | T2170 | TargetMol Chemicals
CAS: 130495-35-1
Smiles: Cl.COc1ccc(CCCOC(Cn2ccnc2)c2ccc(OC)cc2)cc1
Formula: C22H27ClN2O3
Pathway: Apoptosis|||Autophagy|||Membrane transporter/Ion channel|||Metabolism
Target: Apoptosis|||Potassium Channel|||Calcium Channel|||TRP/TRPV Channel|||Autophagy
Receptor: N/A
Bioactivity: SKF-96365, a SOCE inhibitor, exhibits potent anti-neoplastic activity by inducing cell-cycle arrest and apoptosis in colorectal Y cells. SKF-96365 can induce cytoprotective autophagy to delay apoptosis by preventing the release of cytochrome c (cyt c) from the mitochondria into the cytoplasm. Mechanistically, SKF-96365 treatment inhibited the calcium/calmodulin-dependent protein kinase IIγ (CaMKIIγ)/AKT signaling cascade in vitro and in vivo. Overexpression of CaMKIIγ or AKT abolished the effects of SKF-96365 on Y cells, suggesting a critical role of the CaMKIIγ/AKT signaling pathway in SFK-96365-induced biological effects. SKF-96365 inhibited hERG current in a concentration-dependent manner.
Molecular Weight: 402, 92
