Product Overview
SNIPER(BRD)-1 | T16905 | TargetMol Chemicals
CAS: 2095244-54-3
Smiles: CN[C@@H](C)C(=O)N[C@@H](C1CCCCC1)C(=O)N1CCC[C@H]1c1nc(cs1)C(=O)c1cccc(OCCOCCOCCOCCNC(=O)C[C@@H]2N=C(c3c(C)c(C)sc3-n3c(C)nnc23)c2ccc(Cl)cc2)c1
Formula: C53H66ClN9O8S2
Pathway: Others
Target: Others
Receptor: N/A
Bioactivity: SNIPER(BRD)-1, consists of an IAP antagonist LCL-161 derivative and a BET inhibitor, (+)-JQ-1, connected by a linker. SNIPER(BRD)-1 induces the degradation of BRD4 via the ubiquitin-proteasome pathway. SNIPER(BRD)-1 also degrades cIAP1, cIAP2 and XIAP with IC50s of 6.8 nM, 17 nM, and 49nM, respectively[1].
Molecular Weight: 1056, 74
