Product Overview
Spiruchostatin A | T28836 | TargetMol Chemicals
CAS: 328548-11-4
Smiles: CC(C)[C@H]1NC(=O)[C@H]2CSSCC\C=C\[C@H](CC(=O)N[C@H](C)C(=O)N2)OC(=O)C[C@@H]1O
Formula: C20H31N3O6S2
Pathway: N/A
Target: N/A
Receptor: N/A
Bioactivity: Spiruchostatin A is a histone deacetylase (HDAC) inhibitor. When the U937 cells were treated with Spiruchostatin A, evidence of apoptotic features, including changes in nuclear morphology and increase in DNA fragmentation, were obtained. Spiruchostatin A-induced acetylation of specific lysine residues within histones H3 and H4, and increased the expression of p21(cip1/waf1), but did not induce acetylation of alpha-tubulin.
Molecular Weight: 473, 6