Product Overview
SR-318 | T12997 | TargetMol Chemicals
CAS: 2413286-32-3
Smiles: Nc(n(-c1ccccc1)nc1)c1C(NCc(cc1)ccc1C(NCCCC1CCCCC1)=O)=O
Formula: C27H33N5O2
Pathway: Apoptosis|||MAPK
Target: p38 MAPK|||TNF
Receptor: N/A
Bioactivity: SR-318 potently inhibits the TNF-α release in whole blood (IC50 = 283 nM). SR-318 is a potent and highly selective inhibitor of p38 MAPK. The IC50 values are 5 nM, 32 nM and 6.11 μM for p38α, p38β and p38α/β, respectively.
Molecular Weight: 459, 58
