Product Overview
STL127705 | T13017 | TargetMol Chemicals
CAS: 1326852-06-5
Smiles: COc1ccc(CCNc2ncc3c(n2)[nH]c(=O)n(-c2cccc(F)c2)c3=O)cc1OC
Formula: C22H20FN5O4
Pathway: DNA Damage/DNA Repair|||Others|||PI3K/Akt/mTOR signaling
Target: DNA-PK|||Others
Receptor: N/A
Bioactivity: STL127705 is a potent Ku 70/80 heterodimer protein inhibitor and inhibits Ku70/80-DNA interaction with IC50 of 3.5 μM. STL127705 inhibits the activation of Ku-dependent DNA-PKCS kinase with IC50 of 2.5 μM.
Molecular Weight: 437, 431