Product Overview
Su1498 | T3980 | TargetMol Chemicals
CAS: 168835-82-3
Smiles: CC(C)c1cc(\C=C(/C#N)C(=O)NCCCc2ccccc2)cc(C(C)C)c1O
Formula: C25H30N2O2
Pathway: Angiogenesis|||Tyrosine Kinase/Adaptors
Target: VEGFR
Receptor: N/A
Bioactivity: SU 1498 is a selective inhibitor of the receptor tyrosine kinase VEGF receptor 2 (VEGFR2, aka FLK1; IC50 = 700 nM), having negligible activity at several other serine/threonine and tyrosine kinases.1, 2 It effectively blocks signaling through VEGFR2 both in vitro and in vivo.1, 3 SU 1498 is used to study the role of VEGFR2 signaling in diverse processes, including angiogenesis, tumor growth, neural progenitor cell survival, and neuroregeneration.
Molecular Weight: 390, 527