Product Overview
SU16f | T16947 | TargetMol Chemicals
CAS: 251356-45-3
Smiles: Cc1[nH]c(\C=C2/C(=O)Nc3cc(ccc23)-c2ccccc2)c(C)c1CCC(O)=O
Formula: C24H22N2O3
Pathway: Angiogenesis|||Tyrosine Kinase/Adaptors
Target: PDGFR
Receptor: N/A
Bioactivity: SU16f is a potent and selective PDGFRβ inhibitor (IC50s: 10 nM, 140 nM, 2.29 μM for PDGFRβ, PDGFR1, PDGFR2, respectively). Neutralization of PDGFRβ receptor by SU16f blocks the promoting role of GC-MSCs conditioned medium in gastric cancer cell proliferation and migration.
Molecular Weight: 386, 451