Product Overview
Sulfaphenazole | T4567 | TargetMol Chemicals
CAS: 526-08-9
Smiles: Nc1ccc(cc1)S(=O)(=O)Nc1ccnn1-c1ccccc1
Formula: C15H14N4O2S
Pathway: Metabolism|||Microbiology/Virology
Target: P450|||Antibacterial
Receptor: N/A
Bioactivity: Sulfaphenazole is an inhibitor of CYP2C9 (Ki: 0.3 μM) that demonstrates at least 100-fold selectivity over other CYP450 isoforms (Ki: 63/29 μM for CYP2C8/CYP2C18, respectively, and no activity at CYP1A1, CYP1A2, CYP3A4, CYP2C19). At 10 μM, sulfaphenazole has been shown to inhibit endothelium-derived hyperpolarizing factor synthase, a CYP450 isozyme in the porcine coronary artery homologous to CYP2C8/9 that generates reactive oxygen species in coronary endothelial cells and modulates vascular tone and homeostasis.
Molecular Weight: 314, 36
