Product Overview
Suramin Sodium Salt | T2160 | TargetMol Chemicals
CAS: 129-46-4
Smiles: [Na+].[Na+].[Na+].[Na+].[Na+].[Na+].Cc1ccc(cc1NC(=O)c1cccc(NC(=O)Nc2cccc(c2)C(=O)Nc2cc(ccc2C)C(=O)Nc2ccc(c3cc(cc(c23)S([O-])(=O)=O)S([O-])(=O)=O)S([O-])(=O)=O)c1)C(=O)Nc1ccc(c2cc(cc(c12)S([O-])(=O)=O)S([O-])(=O)=O)S([O-])(=O)=O
Formula: C51H34N6Na6O23S6
Pathway: Apoptosis|||Chromatin/Epigenetic|||DNA Damage/DNA Repair|||Metabolism|||Microbiology/Virology
Target: Apoptosis|||Phosphatase|||SARS-CoV|||Sirtuin|||Reverse Transcriptase|||Topoisomerase|||Parasite
Receptor: N/A
Bioactivity: Suramin Sodium is a sodium salt form of suramin, a polysulphonated naphthylurea with potential antineoplastic activity. Suramin blocks the binding of various growth factors, including insulin-like growth factor I (IGF-I), epidermal growth factor (EGF), platelet-derived growth factor (PDGF), and tumor growth factor-beta (TGF-beta), to their receptors, thereby inhibiting endothelial cell proliferation and migration. This agent also inhibits vascular endothelial growth factor (VEGF)- and basic fibroblast growth factor (bFGF)-induced angiogenesis; retroviral reverse transcriptase; uncoupling of G-proteins from receptors; topoisomerases; cellular folate transport; and steroidogenesis.
Molecular Weight: 1429, 15
