Product Overview
T863 | T4681 | TargetMol Chemicals
CAS: 701232-20-4
Smiles: CC1(C)Oc2ncnc(N)c2N=C1c1ccc(cc1)[C@H]1CC[C@H](CC(O)=O)CC1
Formula: C22H26N4O3
Pathway: Metabolism
Target: Acyltransferase|||Transferase
Receptor: N/A
Bioactivity: T-863(DGAT-1 inhibitor) is an orally active, selective and potent DGAT1 (Acyl-CoA:diacylglycerol acyltransferase 1) inhibitor that interacts with the acyl-CoA binding site of DGAT1, and inhibits triacylglycerol synthesis in cells. IC50 value: Target: DGAT1 T863 causes weight loss, reduction in serum and liver triglycerides, and improved insulin sensitivity in obese mice.
Molecular Weight: 394, 47
