Taccalonolide A | TN2254

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€356.00 - €625.00
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TMC-TN2254
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Product Overview

Taccalonolide A | TN2254 | TargetMol Chemicals

CAS: 108885-68-3

Smiles: [H][C@@]12[C@H](OC(C)=O)[C@@]3([H])[C@]4([H])[C@@H](O)C(=O)[C@@]5([H])C[C@@H]6O[C@@H]6[C@H](OC(C)=O)[C@]5(C)[C@@]4([H])[C@H](OC(C)=O)[C@H](OC(C)=O)[C@]3(C)[C@@]1([H])[C@H](C)C=C1OC(=O)[C@@](C)(O)[C@]21C

Formula: C36H46O14

Pathway: Apoptosis|||Cytoskeletal Signaling

Target: Apoptosis|||Microtubule Associated

Receptor: N/A

Bioactivity: Taccalonolide A is the first microtubule stabilizing agent to be discovered from a plant since identification of the mechanism of action of paclitaxel and it is the first natural product steroid identified to have these cellular effects, with cytotoxic and antimalarial activities. Taccalonolide A causes G2-M accumulation, Bcl-2 phosphorylation and initiation of apoptosis. Taccalonolide A is effective in vitro against cell lines that overexpress P-glycoprotein (Pgp) and multidrug resistance protein 7 (MRP7), with an IC50 of 622 nM for SK-OV-3 cells.

Molecular Weight: 702, 75

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