Product Overview
Tacrolimus monohydrate | T20879 | TargetMol Chemicals
CAS: 109581-93-3
Smiles: O=C([C@@](CCCC1)([H])N1C(C([C@@]2(O)[C@H](C)C[C@H](OC)[C@@](O2)([H])[C@@H](OC)C[C@@H](C)C/C(C)=C/[C@H]3CC=C)=O)=O)O[C@H](/C(C)=C/[C@H]4C[C@@H](OC)[C@H](O)CC4)[C@H](C)[C@@H](O)CC3=O.O
Formula: C44H71NO13
Pathway: Autophagy|||Metabolism|||Microbiology/Virology|||Others
Target: Phosphatase|||Others|||Antibacterial|||Antibiotic|||Autophagy
Receptor: N/A
Bioactivity: Tacrolimus hydrate is a macrolide from the culture broth of a strain of Streptomyces tsukubaensis, binds to FK506 binding protein (FKBP) to form a complex. Tacrolimus inhibits calcineurin phosphatase, which inhibits T-lymphocyte signal transduction and IL-2 transcription. Immunosuppressive properties. It prevents the activation of T-lymphocytes in response to antigenic or mitogenic stimulation in vitro and has strong immunosuppressive activity in vivo.
Molecular Weight: 822, 05
