Product Overview
TAK-243 | T16974 | TargetMol Chemicals
CAS: 1450833-55-2
Smiles: NS(=O)(=O)OC[C@H]1C[C@@H](Nc2ccnc3cc(nn23)-c2cccc(SC(F)(F)F)c2)[C@H](O)[C@@H]1O
Formula: C19H20F3N5O5S2
Pathway: Apoptosis|||NF-Īb|||Ubiquitination
Target: Apoptosis|||E1/E2/E3 Enzyme|||NF-ĪŗB
Receptor: N/A
Bioactivity: TAK-243 is a small molecule inhibitor of ubiquitin-activating enzyme (UAE, IC50=1 nM), which blocks ubiquitin conjugation, disrupting monoubiquitin signaling as well as global protein ubiquitination. TAK-243 (MLN7243) induces endoplasmic reticulum (ER) stress, abrogates NF-ĪŗB pathway activation and promotes apoptosis, with potential antineoplastic activity.
Molecular Weight: 519, 51
