Product Overview
TAK-285 | T6039 | TargetMol Chemicals
CAS: 871026-44-7
Smiles: CC(C)(O)CC(=O)NCCn1ccc2ncnc(Nc3ccc(Oc4cccc(c4)C(F)(F)F)c(Cl)c3)c12
Formula: C26H25ClF3N5O3
Pathway: Angiogenesis|||Cell Cycle/Checkpoint|||Chromatin/Epigenetic|||JAK/STAT signaling|||MAPK|||Tyrosine Kinase/Adaptors
Target: EGFR|||MEK|||HER|||Aurora Kinase
Receptor: N/A
Bioactivity: TAK-285 is a novel dual HER2 and EGFR(HER1) inhibitor with IC50 of 17 nM and 23 nM, >10-fold selectivity for HER1/2 than HER4, less potent to MEK1/5, c-Met, Aurora B, Lck, CSK etc. Phase 1.
Molecular Weight: 547, 96
