Product Overview
Talniflumate | T4503 | TargetMol Chemicals
CAS: 66898-62-2
Smiles: FC(F)(F)c1cccc(Nc2ncccc2C(=O)OC2OC(=O)c3ccccc23)c1
Formula: C21H13F3N2O4
Pathway: Immunology/Inflammation|||Membrane transporter/Ion channel|||Metabolism|||Neuroscience
Target: Chloride channel|||COX|||N-Acetylglucosaminyltransferase|||Anion Exchanger
Receptor: N/A
Bioactivity: Talniflumate is a calcium-activated chloride channel (hCLCA1/mCLCA3) blocker that reduces mucin synthesis and releases in animal models and cell culture. It possesses anti-inflammatory actions via inhibition of Cox (cyclooxygenase) and inhibits Cl-/HCO3- exchange activity. It also increases survival in a cystic fibrosis mouse model of the distal intestinal obstructive syndrome.
Molecular Weight: 414, 34
