Product Overview
Tandutinib | T1667 | TargetMol Chemicals
CAS: 387867-13-2
Smiles: COc1cc2c(ncnc2cc1OCCCN1CCCCC1)N1CCN(CC1)C(=O)Nc1ccc(OC(C)C)cc1
Formula: C31H42N6O4
Pathway: Angiogenesis|||Apoptosis|||Tyrosine Kinase/Adaptors
Target: Apoptosis|||FLT|||CSF-1R|||PDGFR|||Src|||c-Kit
Receptor: N/A
Bioactivity: Tandutinib (MLN518, CT53518), an effective FLT3 antagonist (IC50: 0.22 μM), can also inhibit c-Kit and PDGFR, 15-20 fold higher potency for FLT3 versus CSF-1R and >100-fold selectivity for the same target versus FGFR, EGFR, and KDR.
Molecular Weight: 562, 715
