Product Overview
Tanshinone IIB | TN2257 | TargetMol Chemicals
CAS: 17397-93-2
Smiles: Cc1coc-2c1C(=O)C(=O)c1c3CCC[C@](C)(CO)c3ccc-21
Formula: C19H18O4
Pathway: Apoptosis|||Membrane transporter/Ion channel|||Neuroscience|||Proteases/Proteasome
Target: BCL|||Caspase|||P-gp
Receptor: N/A
Bioactivity: Co-treatment with Tanshinone IIB (TSB) significantly inhibits the DNA laddering, cytotoxicity and apoptosis of rat cortical neurons induced by staurosporine in a concentration-dependent manner; TSB also suppresses the elevated Bax protein and decreased bcl-2 and caspase-3 proteins induced by staurosporine in rat cortical neurons; TSB is effective in reducing stroke-induced brain damage and may represent a novel drug candidate for further development.
Molecular Weight: 310, 349
