Product Overview
TAS05567 | T16995 | TargetMol Chemicals
CAS: 1429038-15-2
Smiles: Cc1cc(Nc2nc(N[C@@H]3CCOC[C@@H]3N)nnc2C(N)=O)cc2cn(nc12)C(C)(C)C
Formula: C21H29N9O2
Pathway: Angiogenesis|||Apoptosis|||Chromatin/Epigenetic|||JAK/STAT signaling|||Stem Cells|||Tyrosine Kinase/Adaptors
Target: FLT|||c-RET|||JAK|||Syk
Receptor: N/A
Bioactivity: TAS05567 is a potent, highly selective, and ATP-competitive Syk inhibitor (IC50: 0.37 nM). TAS05567 only shows >70% inhibition of Syk and 4 other kinases (FLT3, JAK2, KDR, and RET with IC50s of 10 nM, 4.8 nM, 600 nM, and 29 nM, respectively) in a panel of 192 kinases.
Molecular Weight: 439, 524