Product Overview
TAT-cyclo-CLLFVY | TP2046 | TargetMol Chemicals
CAS: 1446322-66-2
Smiles:
Formula: C111H188N42O24S2
Pathway: N/A
Target: N/A
Receptor: N/A
Bioactivity: Selective HIF-1 dimerization inhibitor. Blocks protein-protein interaction of recombinant HIF-1α, but not HIF-2α, with HIF-1β (IC50 = 1.3 μM). Inhibits hypoxia-induced HIF-1 activity, and decreases VEGF and CAIX expression in osteosarcoma and breast cancer cells in vitro. Also reduces tubularization of hypoxic HUVECs.
Molecular Weight: 2559, 1
