Product Overview
TC-S 7009 | T17009 | TargetMol Chemicals
CAS: 1422955-31-4
Smiles: [O-][N+](=O)c1c(Nc2cc(F)cc(Cl)c2)ccc2nonc12
Formula: C12H6ClFN4O3
Pathway: Angiogenesis|||Chromatin/Epigenetic
Target: HIF
Receptor: N/A
Bioactivity: TC-S 7009 is more selective for HIF-2α than HIF-1α (Kd 5 μM). TC-S 7009 is an effective and selective inhibitor of HIF-2α (Kd: 81 nM). TC-S 7009 disrupts HIF-2α heterodimerization, decreases DNA-binding activity, and reduces HIF-2α target gene expression.
Molecular Weight: 308, 65
