Product Overview
Tetrahydroxystilbene-2-O-β-D-glucoside | T4956 | TargetMol Chemicals
CAS: 55327-45-2
Smiles: OC[C@H]1O[C@H]([C@@H]([C@H]([C@@H]1O)O)O)Oc2c(C=Cc3ccc(O)cc3)cc(O)cc2O
Formula: C20H22O9
Pathway: Others
Target: Others
Receptor: N/A
Bioactivity: Tetrahydroxystilbene-2-O-β-D-glucoside is a low MW inducer of erythropoietin. Tetrahydroxystilbene-2-O-β-D-glucoside induces expression of erythropoietin, PPAR-γ coactivator 1α (PGC-1α) and haemoglobin in astrocytes and PC12 neuronal-like cells. In vivo, Tetrahydroxystilbene-2-O-β-D-glucoside treatment restores memory impairment, as assessed by the passive avoidance test, in SD, Aβ and KA mouse models. In the hippocampus of mice given Tetrahydroxystilbene-2-O-β-D-glucoside in their diet, levels of erythropoietin, PGC-1α and haemoglobin were increased. Treatment with Tetrahydroxystilbene-2-O-β-D-glucoside might be a therapeutic strategy for memory impairment in neurodegenerative disease, physiological ageing or traumatic brain injury.
Molecular Weight: 406, 38
