Product Overview
TH287 hydrochloride | T2069L | TargetMol Chemicals
CAS: 1638211-05-8
Smiles: Cl.CNc1cc(nc(N)n1)-c1cccc(Cl)c1Cl
Formula: C11H11Cl3N4
Pathway: Cell Cycle/Checkpoint|||DNA Damage/DNA Repair
Target: DNA/RNA Synthesis|||MTH1
Receptor: N/A
Bioactivity: TH287 is a selective MTH1 inhibitor(IC50 : 0.8 nM). It causees incorporation of oxidized dNTPs in cancer cells, leading to DNA damage, cytotoxicity and therapeutic responses in patient-derived mouse xenografts.
Molecular Weight: 305, 59
