Product Overview
Thiocolchicine | T41248 | TargetMol Chemicals
CAS: 2730-71-4
Smiles: COc1cc2CC[C@H](NC(C)=O)c3cc(=O)c(SC)ccc3-c2c(OC)c1OC
Formula: C22H25NO5S
Pathway: Cytoskeletal Signaling
Target: Microtubule Associated
Receptor: N/A
Bioactivity: Thiocolchicine is an effective inhibitor of tubulin polymerization with an IC50 of 2.5 µM and a Ki of 0.7 µM. Thiocolchicine induces cell apoptosis. Thiocolchicine can be used as an ADC cytotoxin in ADC technology.
Molecular Weight: 415, 5