Product Overview
Tipifarnib | T6271 | TargetMol Chemicals
CAS: 192185-72-1
Smiles: Cn1cncc1[C@@](N)(c1ccc(Cl)cc1)c1ccc2n(C)c(=O)cc(-c3cccc(Cl)c3)c2c1
Formula: C27H22Cl2N4O
Pathway: Metabolism
Target: Transferase
Receptor: N/A
Bioactivity: Tipifarnib is a nonpeptidomimetic quinolinone with potential antineoplastic activity. Tipifarnib binds to and inhibits the enzyme farnesyl protein transferase, an enzyme involved in protein processing (farnesylation) for signal transduction. By inhibiting the farnesylation of proteins, this agent prevents the activation of Ras oncogenes, inhibits cell growth, induces apoptosis, and inhibits angiogenesis.
Molecular Weight: 489, 4
