Product Overview
TLI3-12 | T34891 | TargetMol Chemicals
CAS: T34891
Smiles: O=C(NCCOCCOCCN1CCN(C2=CC=C(NC3=NC=C(Cl)C(NC4=CC=CC=C4S(=O)(C(C)C)=O)=N3)C(OC)=C2)CC1)CNC5=CC=CC(C(N6C(CC7)C(NC7=O)=O)=O)=C5C6=O
Formula: C45H53ClN10O10S
Pathway: N/A
Target: N/A
Receptor: N/A
Bioactivity: TLI3-12 is the first small molecule degrader. It induces anaplastic lymphoma kinase (ALK) degradation, including that in non-small-cell lung cancer (NSCLC), anaplastic large-cell lymphoma (ALCL), and neuroblastoma (NB) cell lines.
Molecular Weight: 961, 49
