Product Overview
Tolebrutinib | T9125 | TargetMol Chemicals
CAS: 1971920-73-6
Smiles: C=CC(N(CCC1)C[C@@H]1N(c(ccnc1N)c1N1c(cc2)ccc2Oc2ccccc2)C1=O)=O
Formula: C26H25N5O3
Pathway: Angiogenesis|||Tyrosine Kinase/Adaptors
Target: BTK
Receptor: N/A
Bioactivity: Tolebrutinib is a potent, selective, orally active and brain-penetrant Bruton tyrosine kinase (BTK) inhibitor(IC50s of 0.4 and 0.7 nM in Ramos B cells and in HMC microglia cells, respectively). It exhibits efficacy in central nervous system immunity. Tolebrutinib can be used for the research of multiple sclerosis (MS).
Molecular Weight: 455, 51