Product Overview
Torin 2 | T6100 | TargetMol Chemicals
CAS: 1223001-51-1
Smiles: Nc1ccc(cn1)-c1ccc2ncc3ccc(=O)n(-c4cccc(c4)C(F)(F)F)c3c2c1
Formula: C24H15F3N4O
Pathway: Apoptosis|||Autophagy|||DNA Damage/DNA Repair|||PI3K/Akt/mTOR signaling
Target: Apoptosis|||ATM/ATR|||DNA-PK|||mTOR|||Autophagy
Receptor: N/A
Bioactivity: Torin 2(IC50=0.25 nM), a specific and effective mTOR inhibitor, is the 800-fold greater specific activity for mTOR than PI3K and improves pharmacokinetic properties. The EC50 of Torin 2 for ATM/ATR/DNA-PK inhibition is 28 nM/35 nM/118 nM, respectively.
Molecular Weight: 432, 406
