Product Overview
TP0427736 | T24897 | TargetMol Chemicals
CAS: 864374-00-5
Smiles: Cc1csc(n1)-c1nc[nH]c1-c1ccc2ncsc2c1
Formula: C14H10N4S2
Pathway: Stem Cells
Target: TGF-beta/Smad
Receptor: N/A
Bioactivity: TP0427736 is a potent and selective inhibitor of ALK5 with an IC50 of 2.72 nM, 300-fold higher than the inhibitory effect on ALK3. TP0427736 reduces TGF-β-induced growth inhibition in human outer root sheath cells and elongates the anagen phase in mouse hair follicles.
Molecular Weight: 298, 38