TPCS2a | T34909

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TMC-T34909
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Product Overview

TPCS2a | T34909 | TargetMol Chemicals

CAS: 501083-97-2

Smiles: OS(=O)(=O)c1ccc(cc1)-c1c2CCc(n2)c(-c2ccc(cc2)S(O)(=O)=O)c2ccc([nH]2)c(-c2ccccc2)c2ccc(n2)c(-c2ccccc2)c2ccc1[nH]2

Formula: C44H32N4O6S2

Pathway: N/A

Target: N/A

Receptor: N/A

Bioactivity: TPCS2a, also know as, tetraphenyl chlorin disulfonate, is a meso-tetraphenylchlorin substituted by two adjacent sulfonated groups with potential photosensitizing activity. Upon administration, tetraphenyl chlorin disulfonate incorporates into the cellÂ’s endosome and lysosome membranes. Subsequently, cytotoxic agents are administered and accumulate in endosomal and lysosomal compartments; upon local activation by light, tetraphenyl chlorin disulfonate produces reactive oxygen species (ROS), such as singlet oxygen, damaging endo/lysosomal membranes and accumulated cytotoxic agents are released into the tumor cell cytosol.

Molecular Weight: 776, 88

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