Product Overview
Tretazicar | T6798 | TargetMol Chemicals
CAS: 21919-05-1
Smiles: NC(=O)c1cc(N2CC2)c(cc1[N+]([O-])=O)[N+]([O-])=O
Formula: C9H8N4O5
Pathway: DNA Damage/DNA Repair
Target: DNA Alkylator/Crosslinker|||DNA Alkylation
Receptor: N/A
Bioactivity: CB1954(Tretazicar), an anticancer prodrug, is activated by NAD(P)H quinone oxidoreductase 2. It is converted in the presence of the enzyme NQO2 and co-substrate caricotamide ( EP-0152R) (EP) into a potent cytotoxic bifunctional alkylating agent.
Molecular Weight: 252, 186