Product Overview
Trichostatin A | T6270 | TargetMol Chemicals
CAS: 58880-19-6
Smiles: C[C@H](\C=C(/C)\C=C\C(=O)NO)C(=O)c1ccc(cc1)N(C)C
Formula: C17H22N2O3
Pathway: Chromatin/Epigenetic|||DNA Damage/DNA Repair
Target: HDAC
Receptor: N/A
Bioactivity: Trichostatin A is a natural derivative of dienohydroxamic acid isolated from species of the bacterial genus Streptomyces. Trichostatin A (TSA) reversibly and specifically inhibits histone deacetylases, resulting in hyperacetylation of core histones which modulate chromatin structure. The increase in histone acetylation promotes selective gene transcription and the inhibition of tumor growth. This agent is a potent inducer of tumor cell growth arrest, differentiation and apoptosis in a variety of transformed cells in culture and in tumor-bearing animals.
Molecular Weight: 302, 374
