Product Overview
TTA-A2 | T8944 | TargetMol Chemicals
CAS: 953778-63-7
Smiles: C[C@@H](NC(=O)Cc1ccc(cc1)C1CC1)c1ccc(OCC(F)(F)F)cn1
Formula: C20H21F3N2O2
Pathway: Membrane transporter/Ion channel|||Metabolism
Target: Calcium Channel
Receptor: N/A
Bioactivity: TTA-A2 is a selective T-type calcium channel antagonist as a potent anticonvulsant that the Cav3.1 isoform plays a prominent role in mediating. TTA-A2 is equally potent against the Cav3.1 (a1G) and Cav3.2 (a1H) channels with IC50 values of 89 nM and 92 nM, respectively, at -80 and -100 mV holding potentials. TTA-A2 can be used for the research of a variety of human neurological diseases, including sleep disorders and epilepsy.
Molecular Weight: 378, 395
