Product Overview
Tucidinostat | T4481 | TargetMol Chemicals
CAS: 1616493-44-7
Smiles: Nc1cc(F)ccc1NC(=O)c1ccc(CNC(=O)\C=C\c2cccnc2)cc1
Formula: C22H19FN4O2
Pathway: Chromatin/Epigenetic|||DNA Damage/DNA Repair
Target: HDAC
Receptor: N/A
Bioactivity: Tucidinostat is an effective and orally bioavailable HDAC enzymes class I (HDAC1/2/3) and class IIb (HDAC10) inhibitor, with IC50s of 95, 160, 67 and 78 nM, less active on HDAC8/11 (IC50: 733/432 nM), and shows no effect on HDAC4/5/6/7/9.
Molecular Weight: 390, 418
