Product Overview
UNBS-1450 | T29060 | TargetMol Chemicals
CAS: 676541-58-5
Smiles: [H][C@@]12CC[C@]3([H])[C@]([H])(CC[C@]4(C)[C@H](CC[C@]34O)C3=CC(=O)OC3)[C@@]1(CO)C[C@]1([H])O[C@]3(O)[C@@]([H])(O[C@H](C)C[C@@]33NC(=O)CS3)O[C@@]1([H])C2
Formula: C31H43NO9S
Pathway: N/A
Target: N/A
Receptor: N/A
Bioactivity: UNBS-1450 is a sodium channel antagonist. UNBS-1450 is a hemi-synthetic cardenolide derived from 2″-oxovorusharin, it is effective against various cancer cell types with an excellent differential toxicity. At low nanomolar concentrations, UNBS-1450 induces apoptotic cell death. UNBS-1450 inhibits NF-κB transactivation and triggers apoptosis by cleavage of pro-caspases 8, 9 and 3/7, by decreasing expression of anti-apoptotic Mcl-1 and by recruitment of pro-apoptotic Bak and Bax protein eventually resulting in cell death.
Molecular Weight: 605, 74
