Product Overview
Uncarinic acid E | TN5201 | TargetMol Chemicals
CAS: 277751-61-8
Smiles: CC1(C)CC[C@@]2(CC[C@]3(COC(=O)\C=C\c4ccc(O)cc4)C(=CC[C@@H]4[C@@]5(C)CC[C@H](O)C(C)(C)[C@@H]5CC[C@@]34C)[C@@H]2C1)C(O)=O
Formula: C39H54O6
Pathway: Apoptosis|||MAPK|||Microbiology/Virology|||PI3K/Akt/mTOR signaling|||Proteases/Proteasome
Target: BCL|||MEK|||Caspase|||PI3K|||Antifection|||p53
Receptor: N/A
Bioactivity: Uncarinic acid E has anti-cancer activity, it induces apoptosis in HepG2 cells via accumulation of p53, alters the Bax/Bcl-2 ratio, and activates caspases, resulting in cytochrome c release from the mitochondria. A mixture of uncarinic acid E and 27-O-p-(E)-coumaroyloxyursolic acid exhibits antiplasmodial activity, with the IC50 value of 2.9 microg/ml.
Molecular Weight: 618, 84
