Product Overview
UNIL-088 | T34999 | TargetMol Chemicals
CAS: 473545-11-8
Smiles: CC[C@@H]1NC(=O)[C@H]([C@H](OC(=O)CN(C)C(=O)[C@H](COP(O)(O)=O)NC(=O)OC(C)OC(C)=O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O)C(C)C
Formula: C73H128N13O22P
Pathway: N/A
Target: N/A
Receptor: N/A
Bioactivity: UNIL088 is a water-soluble prodrug of cyclosporine A (CsA) designed for topical ocular delivery. The pro-moiety is grafted via an ester function to CsA and the solubilizing group is a phosphate ion. UNIL-088 can be rapidly hydrolysed under physiological conditions, and can retain a long shelf-life in aqueous media. UNIL-088 is more stable at pH 5 than at pH 7 with conversion rate constant of 3.2 x 10(-3) and 26.0 x 10(-3)days(-1), respectively.
Molecular Weight: 1570, 87
