Product Overview
Urantide acetate(669089-53-6 free base) | TP2106L | TargetMol Chemicals
CAS: TP2106L
Smiles: CC([C@@H](C(O)=O)NC([C@@H]1CSSC(C)([C@H](C(N[C@H](C(N[C@@H](C(N[C@H](C(N[C@H](C(N1)=O)Cc2ccc(O)cc2)=O)CCCN)=O)Cc(c[nH]3)c4c3cccc4)=O)Cc5ccccc5)=O)NC([C@H](CC(O)=O)N)=O)C)=O)C.CC(O)=O
Formula: C53H70N10O14S2
Pathway: GPCR/G Protein
Target: Neurotensin Receptor
Receptor: N/A
Bioactivity: Urantide acetate is a selective and competitive urotensin-II (UT) receptor antagonist (pKB = 8.3). Blocks hU-II induced contractions in thoracic aorta ex vivo. Exhibits no effect on noradrenaline or endothelin 1-induced contraction or on acetylcholine-induced relaxation. Behaves as a partial agonist in a calcium mobilization assay (in CHO cells expressing hUT receptors).
Molecular Weight: 1135, 31
