Product Overview
URMC-099 | T6057 | TargetMol Chemicals
CAS: 1229582-33-5
Smiles: CN1CCN(Cc2ccc(cc2)-c2cnc3[nH]cc(-c4ccc5[nH]ccc5c4)c3c2)CC1
Formula: C27H27N5
Pathway: Angiogenesis|||Autophagy|||Cell Cycle/Checkpoint|||Chromatin/Epigenetic|||Cytoskeletal Signaling|||DNA Damage/DNA Repair|||MAPK|||Metabolism|||Stem Cells|||Tyrosine Kinase/Adaptors
Target: ROCK|||MLK|||VEGFR|||SGK|||DNA Alkylation|||Trk receptor|||c-Met/HGFR|||LRRK2|||MEK|||IGF-1R|||Syk|||Bcr-Abl|||CDK|||Src|||Aurora Kinase|||Autophagy
Receptor: N/A
Bioactivity: URMC-099 is an orally bioavailable, brain penetrant MLK inhibitor (IC50: 19/42/14/150 nM, for MLK1/MLK2/MLK3/DLK), and also inhibits LRRK2 activity (IC50: 11 nM).
Molecular Weight: 421, 548
